Epson Stylus Pro 4000 Reference Manual page 91

Standard double-sided printing
To print odd and even numbered pages onto opposite sides of the
sheet, follow these steps.
1. Select Double-Sided Printing.
2. Click Margins. The following dialog box appears.
3. Specify the edge of the paper where the binding will be
placed. You can choose between Left, Top, and Right.
Printing with Windows
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