Waters ACQUITY UPLC Overview And Maintenance Manual
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Waters ACQUITY UPLC Overview And Maintenance Manual

Quaternary solvent manager
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ACQUITY UPLC Quaternary Solvent
Manager
Overview and Maintenance Guide
715005050
Copyright © Waters Corporation 2016
Revision C
All rights reserved

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Summary of Contents for Waters ACQUITY UPLC

  • Page 1 ACQUITY UPLC Quaternary Solvent Manager Overview and Maintenance Guide 715005050 Copyright © Waters Corporation 2016 Revision C All rights reserved...

  • Page 2: General Information

    This document is believed to be complete and accurate at the time of publication. In no event shall Waters Corporation be liable for incidental or consequential damages in connection with, or arising from, its use. For the most recent revision of this document, consult the Waters Web site (waters.com).

  • Page 3: Contacting Waters

    Contacting Waters Contact Waters with enhancement requests or technical questions regarding the use, transportation, removal, or disposal of any Waters product. You can reach us via the Internet, telephone, or conventional mail. Waters contact information Contacting medium Information Internet The Waters Web site includes contact information for Waters locations worldwide.

  • Page 4: Electrical Power Safety Notice

    To avoid electrical shock, observe these precautions: • Use SVT-type power cord in the United States and HAR-type power cord, or better, in Europe. For requirements elsewhere, contact your local Waters distributor. • Inspect the power cord for damage, and replace it, if necessary.

  • Page 5: Applicable Symbols

    Electrical and electronic equipment with this symbol may contain hazardous substances and should not be disposed of as general waste. For compliance with the Waste Electrical and Electronic Equipment Directive (WEEE) 2012/19/EU, contact Waters Corporation for the correct disposal and recycling instructions. Serial number...

  • Page 6: Intended Use Of The Qsm

    Intended use of the QSM Waters designed the QSM for use in liquid chromatography applications. The QSM is not intended for use in diagnostic applications. Calibrating To calibrate LC systems, adopt acceptable calibration methods using at least five standards to generate a standard curve.

  • Page 7: Ec Authorized Representative

    EC authorized representative Address Waters Corporation Stamford Avenue Altrincham Road Wilmslow SK9 4AX UK Telephone +44-161-946-2400 +44-161-946-2480 Contact Quality manager August 8, 2016, 715005050 Rev. C Page vii...

  • Page 8: Table Of Contents

    Table of contents General information .......................ii Copyright notice ............................. ii Trademarks............................ii Customer comments..........................ii Contacting Waters ..........................iii Safety considerations..........................iii Safety hazard symbol notice ......................iii Considerations specific to the QSM ....................iii FCC radiation emissions notice...................... iv Electrical power safety notice ......................iv Equipment misuse notice .......................
  • Page 9 2.7.2 Priming a dry solvent manager using a syringe..............36 2.8 Washing the plungers ........................38 2.9 Responding to a leak sensor alarm....................39 3 Maintenance ......................43 3.1 Contacting Waters Technical Service ..................43 3.2 Viewing module information ......................44 3.3 Recommended maintenance schedule..................44 3.3.1 Recommended maintenance schedule for the quaternary solvent manager ...... 44 3.4 Spare parts............................
  • Page 10 3.7 Servicing the air filter in the door....................46 3.8 Replacing the solvent reservoir filters ................... 47 3.9 Replacing the leak sensor......................48 3.10 Replacing the inlet manifold ......................51 3.11 Replacing the low-pressure inlet filters on the GPV outlet ............54 3.12 Replacing the 100-µL mixer/filter ....................56 3.13 Installing or replacing the optional 250-µL mixer/filter..............
  • Page 11 A.1.1 Specific warnings ......................127 A.2 Notices............................128 A.3 Bottles Prohibited symbol ......................128 A.4 Required protection ........................129 A.5 Warnings that apply to all Waters instruments and devices ............129 A.6 Warnings that address the replacing of fuses................133 A.7 Electrical symbols ........................135 A.8 Handling symbols ........................136 B Specifications......................137...

  • Page 12: Overview

    A, B, and C (a total of nine solvents to select from). This document explains the operation of both the QSM and the bioQSM. For information about ordering supplies for either device, visit the Waters website (www.waters.com), or consult your Waters sales representative.

  • Page 13: Gradient Smart Start

    See also: • Auto•Blend Plus Technology for Ion Exchange, Size Exclusion, and Reversed-phase Chromatography • The Auto•Blend Plus videos on the Support tab on the Waters Auto•Blend Plus page. 1.2 Major components The following diagrams show the solvent manager’s major components.
  • Page 14 Figure 1–1: Front view, with door closed On/off switch – Powers the module on and off. Power LED – Indicates the power-on or power-off status of the module. This LED is green when power is on and unlit when power is off. Flow LED –...
  • Page 15 Pressure transducer cable connector port (2) – Connects the pressure transducers, which convert solvent pressure into electrical signals for monitoring. Accumulator pump – Receives solvent from the primary pump and delivers it to the vent valve. Location of the sample manager's purge-solvent degasser – Degasses the sample manager's purge solvent.
  • Page 16 Drip tray – Collects liquid leaks. Mobile phase degasser chamber (4) – Removes dissolved gasses from mobile-phase solvents and exhausts them, along with any condensates, through waste tubing. Note: Vacuum degassing can change the composition of mixed solvents. Inlet manifold – Combines the solvents upstream of the pumps. Valve –...

  • Page 17: Pressure Flow Envelope

    1.3 Pressure flow envelope The QSM, a single pump with a proportioning valve, has a maximum operating pressure of 103,421 kPa (1034 bar, 15,000 psi) at flow rates to 1 mL/min. The maximum operating pressure decreases linearly to 53,779 kPa (538 bar, 7800 psi) at flow rates up to 2.2 mL/min. 1.4 Pressure transducer overview The absolute pressure transducer (APT), which measures the pressure on the low pressure side of the degasser system, is unaffected by altitude or barometric changes.
  • Page 18 Figure 1–4: Solvent management system flow path Solvent flow sequence: The in-line vacuum degasser degasses the solvent. The gradient proportioning valve meters the solvents, prior to pressurization in the pump heads. The inlet manifold blends the metered solvents. The blended solvents flow through the i Valve check valve and into the primary piston chamber.

  • Page 19: Preparation And Operation

    • do not use chloroform, methylene chloride, or toluene; • do not use ethyl acetate, hexane, or tetrahydrofuran (THF) without the hexane/THF compatibility kit for ACQUITY UPLC systems; • do not pressurize solvent reservoirs above 34.5 kPa (0.34 bar, 5 psi).

  • Page 20: Assembling New Fittings

    Recommendations: • To prevent band spreading, ensure that the tubing is fully bottomed in the fitting port before tightening the compression screw. • For easier accessibility, use compression fittings with long flats to attach tubes to the vent valve. • Perform the solvent manager leak test whenever you replace or loosen fittings during maintenance (see the console online Help).

  • Page 21: Stainless Steel (Gold-Plated) Fitting With Short Flats And 2-Piece Stainless-Steel Ferrule

    Mark the fitting body at the 9 o’clock position. Ensure that the tubing makes contact with the bottom of the fitting body, and use the 1/4- inch open-end wrench to rotate the compression screw clockwise 3/4-turn until the two marks line up. 2.1.2 Stainless steel (gold-plated) fitting with short flats and 2-piece stainless-steel ferrule First use...

  • Page 22: Stainless Steel (Gold-Plated) Fitting With Long Flats And 2-Piece Stainless-Steel Ferrule

    Re-installed Short flats Compression screw 2-piece stainless steel ferrule Tighten the fitting finger-tight plus as much as an additional 1/6-turn using a 1/4-inch open-end wrench. Re-installed tightening 2.1.3 Stainless steel (gold-plated) fitting with long flats and 2-piece stainless-steel ferrule First use Long flats Compression screw 2-piece stainless-steel ferrule...
  • Page 23 Tighten the fitting finger-tight plus an additional 3/4-turn using a 1/4-inch open-end wrench. For detailed instructions about assembling new fittings, see Assembling new fittings. Tip: To prevent band spreading, ensure that the tubing is fully bottomed in the fitting before tightening the compression screw.

  • Page 24: 5/16-24 Fitting With Filter And Stainless Steel Lock Ring

    2.1.4 5/16-24 fitting with filter and stainless steel lock ring First use or re-installed Compression screw Lock ring Ferrule and filter End of lock ring with larger inside diameter (ID) Tighten the fitting finger-tight. 2.1.5 Short 1/4-28 fitting with flangeless ferrule and stainless steel lock ring installed on 1/16-inch OD tubing First use or re-installed Compression screw...

  • Page 25: Long 1/4-28 Fitting With Flangeless Ferrule And Stainless Steel Lock Ring Installed On 1/8-Inch Od Tubing

    Tighten the fitting finger-tight. 2.1.6 Long 1/4-28 fitting with flangeless ferrule and stainless steel lock ring installed on 1/8-inch OD tubing First use or re-installed Compression screw Lock ring Ferrule End of lock ring with larger inside diameter (ID) Tighten the fitting finger-tight. 2.2 Installing and routing the waste and degasser vent tubing Notice:...
  • Page 26 Required tools and materials • Chemical-resistant, powder-free gloves • Methanol • Waste tubing To install and route the waste and degasser vent tubing: Wet the barbed drain fitting located at the bottom of the solvent manager with methanol. Hold the back of the drain cup, slide the waste tubing over the barbed drain fitting, and route the tubing to a suitable waste container.
  • Page 27 Barbed drain fitting Drip tray Warning: To avoid releasing potentially harmful solvent vapors into the room, route the degasser vent tubing to a fume hood or other suitable exhaust system. Alternatively, route the tubing to a suitable waste container, ensuring that the tubing's discharge end is at all times elevated above the fluid level.

  • Page 28: Electricity Source

    To avoid electrical shock, observe these precautions: • Use SVT-type power cord in the United States and HAR-type power cord, or better, in Europe. For requirements elsewhere, contact your local Waters distributor. • Inspect the power cord for damage, and replace it, if necessary.

  • Page 29: Connecting Signal Cables

    To avoid electrical shock, observe these precautions: • Use SVT-type power cord in the United States and HAR-type power cord, or better, in Europe. For requirements elsewhere, contact your local Waters distributor. • Inspect the power cord for damage, and replace it, if necessary.
  • Page 30 Figure 2–3: Inserting connector into connector port Connector port Connector Using the flat-blade screwdriver, attach the positive and negative leads of the signal cable to the connector. Figure 2–4: Positive and negative lead connections Screw Connector Signal cable Fit the grounding cable's fork terminal on the rear-panel grounding stud, and secure the terminal using the locking nut.

  • Page 31: Input/Output Signal Connectors

    Figure 2–5: Grounding cable fork terminal on grounding stud Fork terminal Locking nut Grounding stud 2.4.1 Input/output signal connectors Refer to the cable-connection label affixed to the rear panel of the module. Table 2–1: Analog-out/event-in connections Signal connection Description Gradient start Initiates pump operation by either contact-closure input or 0-volt input (an error condition or hardware failure on another instrument or device, for example), beginning a gradient separation.
  • Page 32 Warning: To avoid personal contamination with biohazards or compounds that are toxic, wear clean, chemical-resistant, powder-free gloves when performing this procedure. Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. Required tools and materials • Chemical-resistant, powder-free gloves • Leak sensor To install the leak sensor: Notice: To avoid damaging electrical components and circuitry, do not...

  • Page 33: Priming The Seal-Wash System

    T-bar Slot in leak sensor reservoir Leak sensor port Attach the leak sensor connector to the port on the front of the device. Figure 2–7: Attaching leak sensor connector Leak sensor connector Leak sensor port on front of device Power-on the solvent manager. In the console, select the solvent manager, and then click Control >...
  • Page 34 • Before priming the seal-wash system, ensure the volume of seal wash is adequate for priming. See also: Controlling Contamination in Ultra Performance LC/MS and HPLC/MS Systems (part number 715001307) on the ACQUITY UPLC System Bookshelf CD. Required tools and materials • Chemical-resistant, powder-free gloves • 30-mL syringe (startup kit) •...

  • Page 35: Priming The Solvent Manager

    In the console, select the solvent manager, and then click Control > Prime seal wash > Yes to begin the seal wash priming process. Slowly withdraw the syringe plunger, to pull solvent through the system. When the seal-wash solution begins to flow into the syringe with relatively few air bubbles, click Control >...

  • Page 36: Priming A Dry Solvent Manager Using A Syringe

    Figure 2–9: Location of solvent vent tubing Solvent vent tubing In the console, select the solvent manager, and then click Control > Prime solvents. In the Prime Solvents dialog box, select solvent A, B, C, D, or (instead of D) D through D In the Time box, specify the number of minutes, from 0.1 through 60.0.
  • Page 37 Required tools and materials • Chemical-resistant, powder-free gloves • 30-mL syringe (startup kit) • Seal wash solution • Short length of tubing • Tubing adapter (startup kit) To prime a dry solvent manager using a syringe: Open the solvent manager’s door. Locate the solvent vent tubing from the center port on the vent valve, and follow the tubing down to the drip tray.

  • Page 38: Washing The Plungers

    10. Click Start. 11. Slowly withdraw the syringe plunger. 12. When solvent flows without bubbles from the solvent vent tubing, remove the syringe from the solvent vent tubing. 13. Reinsert the solvent vent tubing into the drip tray. 14. Turn the retainer for the solvent vent tubing, so that it holds the vent tubing in place. Figure 2–11: Solvent vent tubing and retainer Solvent vent tubing Solvent vent tubing retainer...

  • Page 39: Responding To A Leak Sensor Alarm

    • Starts the seal wash pump. • Slowly empties and fills the syringes, with the vent valve set to waste, thus moving the plungers through the seal-wash flow. • Repeats the emptying and filling of syringes for a total of two cycles. To wash the plungers: In the console, select the solvent manager, and then click Maintain >...
  • Page 40 Tip: When a leak is detected, a “Leak Detected” error message appears. Notice: To avoid damaging electrical components and circuitry, do not disconnect an electrical assembly while electrical power is applied to a module. To completely interrupt power, set the on/off switch to the "off" position, and then disconnect the power cord from the ac source.
  • Page 41 Figure 2–13: Leak sensor reservior Leak-sensor reservoir With a cotton swab, absorb any remaining liquid from the corners of the leak-sensor reservoir and its surrounding area. Align the leak sensor’s T-bar with the slot in the side of the leak-sensor reservoir, and slide the leak sensor into place.
  • Page 42 Figure 2–15: Attaching leak sensor connector Leak sensor connector Leak sensor port on front of device 11. Power-on the solvent manager. 12. In the console, select the solvent manager, and then click Control > Reset module, to reset the solvent manager. August 8, 2016, 715005050 Rev.

  • Page 43: Maintenance

    Help. 3.1 Contacting Waters Technical Service If you are located in the USA or Canada, report malfunctions or other problems to Waters Technical Service (800-252-4752). From elsewhere, phone the Waters corporate headquarters in Milford, Massachusetts (USA), or contact your local Waters subsidiary. The Waters Web site includes phone numbers and e-mail addresses for Waters locations worldwide.

  • Page 44: Viewing Module Information

    Be prepared to provide the serial numbers of the modules in your system when you contact Waters customer support. To view module information: In the console, select a module from the system tree.

  • Page 45: Spare Parts

    As necessary cloth, or paper dampened with water 3.4 Spare parts To ensure that your system operates as designed, use only Waters Quality Parts. Visit www.waters.com/wqp for information about Waters Quality Parts, including how to order them. 3.5 Safety and handling...

  • Page 46: Configuring Maintenance Warnings

    Thus you can minimize unexpected failures and unscheduled downtime during important work. For information explaining how to specify maintenance warnings, consult the Waters console Help. 3.7 Servicing the air filter in the door Required tools and materials •...

  • Page 47: Replacing The Solvent Reservoir Filters

    Figure 3–1: Door air filter Air filter Air filter frame Do one of the following: • Clean the air filter using a mild detergent and water, and then dry the filter. • Discard the old air filter. Slide the air filter back into the frame. 3.8 Replacing the solvent reservoir filters Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when...

  • Page 48: Replacing The Leak Sensor

    To replace a solvent reservoir filter: Remove the filtered end of the solvent tubing from the solvent bottle. Remove the old solvent reservoir filter from the short piece of fluoropolymer tubing. Insert the new solvent reservoir filter into the fluoropolymer tubing, pushing until it contacts the solvent tubing.
  • Page 49 Required tools and materials • Chemical-resistant, powder-free gloves • Leak sensor To replace the leak sensor: Notice: To avoid damaging electrical components and circuitry, do not disconnect an electrical assembly while electrical power is applied to a module. To completely interrupt power, set the on/off switch to the "off" position, and then disconnect the power cord from the ac source.
  • Page 50 Figure 3–5: Aligning T-bar with slot T-bar Slot in leak sensor reservoir Leak sensor port on front of device Reinsert the vent tubing into the drip tray. Connect the leak sensor connector to the front of the device. Figure 3–6: Attaching leak sensor connector Leak sensor connector Leak sensor port on front of device Power-on the solvent manager.

  • Page 51: Replacing The Inlet Manifold

    3.10 Replacing the inlet manifold Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. Required tools and materials • Chemical-resistant, powder-free gloves • 1/4-inch open-end wrench • Inlet manifold To replace the inlet manifold: Power-off the solvent manager. Open the solvent manager's door. Disconnect the finger-tight outlet-tubing fitting from the inlet manifold outlet.
  • Page 52 Figure 3–8: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve Use the 1/4-inch open-end wrench to disconnect the inlet-tubing fittings from the inlet manifold. Figure 3–9: Inlet-tubing fittings on manifold Inlet-tubing fitting (4) Remove the inlet manifold from the mounting bracket. Ensuring its groove faces forward, place the new inlet manifold in the mounting bracket.
  • Page 53 Reinstall the outlet-tubing fitting on the side of the i Valve, and minimally tighten it with your fingers. Reattach the inlet-tubing fittings to the inlet manifold, tighten them with your fingers, and then use the 1/4-inch open-end wrench to tighten them an additional 1/6-turn, for existing fittings, or 3/4-turn for new fittings.

  • Page 54: Replacing The Low-Pressure Inlet Filters On The Gpv Outlet

    Figure 3–13: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve 12. Power-on the solvent manager. 13. Prime the solvent manager (see Priming the quaternary solvent manager). 3.11 Replacing the low-pressure inlet filters on the GPV outlet Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials.
  • Page 55 To replace the low-pressure inlet filters on the GPV outlet: Notice: To avoid damaging electrical components and circuitry, do not disconnect an electrical assembly while electrical power is applied to a module. To completely interrupt power, set the on/off switch to the "off" position, and then disconnect the power cord from the ac source.

  • Page 56: Replacing The 100-Μl Mixer/Filter

    Place the new filters on the inlet manifold tubes. Connect the inlet manifold tubes (4) to the GPV outlets and tighten the fittings with your fingers. Power-on the solvent manager. Prime the solvent manager (see Priming the solvent manager). 3.12 Replacing the 100-µL mixer/filter Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials.

  • Page 57: Installing Or Replacing The Optional 250-Μl Mixer/Filter

    Mixer/filter Outlet compression fitting Using the 5/8-inch open-end wrench to hold the mixer/filter, disconnect the inlet compression fittings by using the 1/4-inch wrench. Figure 3–17: Location of inlet compression fitting Inlet compression fitting Mixer/filter Remove the old 100-µL mixer/filter from the bracket. Unpack the new 100-µL mixer/filter.
  • Page 58 Required tools and materials • Chemical-resistant, powder-free gloves • 1/4-inch open-end wrench • 5/8-inch open-end wrench • 250-µL mixer/filter To install or replace the 250-µL mixer/filter: Flush the solvent manager with nonhazardous solvent. Stop the solvent flow. Open the solvent manager’s door. Using the 5/8-inch open-end wrench to hold the mixer/filter in place, disconnect the outlet compression fitting by using the 1/4-inch open-end wrench.

  • Page 59: Replacing The Vent-Valve Cartridge

    Reattach the compression fittings to the 250-µL mixer/filter, and then tighten them with your fingers to the extent possible. 10. Using the 1/4-inch open-end wrench, tighten the fittings an additional 1/6-turn, for existing fittings, or 3/4-turn, for new fittings. 3.14 Replacing the vent-valve cartridge Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials.
  • Page 60 • Orient the new cartridge exactly as the old one was oriented. • The vent-valve cartridge must slide fully into the vent-valve cartridge chamber. If it does not, report the problem to Waters Technical Service. 10. Insert the 2-mm hex screw at the 10 o’clock position on the vent-valve cartridge.

  • Page 61: Replacing The Optional Solvent Selection Valve Cartridge

    Tip: Use the 2-mm hex wrench to tighten it. 11. Use the 1/4-inch open-end wrench to reattach all fittings, and tighten them as much as 1/6- turn beyond finger-tight, for existing fittings, or 3/4-turn beyond finger-tight, for new fittings. 12. Prime the solvent manager (see Priming the solvent manager).
  • Page 62 Figure 3–22: Location of solvent selection valve Solvent selection valve Use the 2-mm hex wrench to remove the hex screw at the 10 o’clock position on the cartridge. Figure 3–23: Hex screw on solvent selection valve cartridge Hex screw Remove the cartridge from the vent valve assembly by pulling straight forward. Unpack the replacement cartridge.

  • Page 63: Replacing The Accumulator Check Valve

    • The cartridge must slide fully into the solvent selection valve assembly. If it does not do so, report the problem to Waters Technical Service. 10. Insert the 2-mm hex screw at the 10 o’clock position on the vent valve cartridge.
  • Page 64 Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. Required tools and materials • Chemical-resistant, powder-free gloves • 1/4-inch open-end wrench • 5/16-inch open-end wrench • 1/2-inch open-end wrench • Accumulator check-valve assembly To replace the accumulator check valve: Flush the solvent manager with nonhazardous solvent.
  • Page 65 Figure 3–26: Check-valve assembly on the accumulator pump head Place the 1/2-inch open-end wrench here Unpack the new check valve. Ensure that the new PEEK washer is inserted into the new check valve so that its chamfered edge faces away from the check valve. Figure 3–27: Accumulator check valve Chamfered edge PEEK washer...

  • Page 66: Replacing The I Valve Actuator And Cartridge

    Wear clean, chemical-resistant, powder-free gloves when performing this procedure. You can replace just the i Valve actuator or cartridge. Recommendation: Waters recommends replacing the i Valve cartridge whenever you replace the actuator. Required tools and materials • Chemical-resistant, powder-free gloves •...

  • Page 67: Removing The I Valve Actuator

    • T8 TORX driver • i Valve actuator (if replacing) • i Valve cartridge (if replacing) Replacing the i Valve actuator and cartridge involves: Removing the i Valve actuator. Removing the i Valve cartridge. Installing the new i Valve cartridge. Installing the i Valve actuator.
  • Page 68 To remove the i Valve actuator: Notice: To avoid damaging electrical components and circuitry, do not disconnect an electrical assembly while electrical power is applied to a module. To completely interrupt power, set the on/off switch to the "off" position, and then disconnect the power cord from the ac source.
  • Page 69 Figure 3–29: Outlet-tubing fitting on manifold Outlet-tubing fitting Inlet manifold Use the 1/4-inch open-end wrench to disconnect the inlet manifold outlet-tubing fitting on the side of the i Valve and remove the tubing. Figure 3–30: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve Use the 5/16-inch open-end wrench to loosen the shell nut, and then fully unscrew it.
  • Page 70 Figure 3–31: Loosening the shell nut Pump head Shell nut Valve Notice: To avoid damaging the i Valve actuator assembly when removing it, • ensure that the PEEK washer, which is normally on the top face of the i Valve cartridge, does not remain in the pump head;...

  • Page 71: Removing The I Valve Cartridge From The Actuator

    3.17.2 Removing the i Valve cartridge from the actuator Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials.

  • Page 72: Installing The I Valve Cartridge On The Actuator

    Tips: • Avoid touching the clamping plate tabs when loosening the screws. • You can rotate the shell nut to gain access to all four screws. When both plates are in the maximum open position, remove the cartridge from the i Valve actuator, and ensure that the low-pressure gasket is removed with the cartridge.
  • Page 73 • Avoid touching the clamping plate tabs when loosening the screws. • You can rotate the shell nut to gain access to all four screws. If you are replacing the i Valve cartridge, unpack the new cartridge. Recommendation: Replace the cartridge whenever you replace the i Valve actuator.
  • Page 74 Figure 3–35: Inserting the cartridge into the i Valve actuator Grooved end of cartridge Valve actuator With one hand, squeeze the 2 clamping plate tabs on the i Valve actuator, to hold the clamping plates against the cartridge. Figure 3–36: i Valve Clamping plates and tabs August 8, 2016, 715005050 Rev.
  • Page 75 Clamping plate tab Clamping plates Clamping plate tab While squeezing the clamping plate tabs, use the T8 TORX driver to tighten the four screws that secure the plates in the order shown below. Repeat the torquing pattern shown below at least three times, gradually increasing the torque until the screws are uniformly tight.

  • Page 76: Installing The I Valve Actuator

    3.17.4 Installing the i Valve actuator Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials. Warning: To avoid personal contamination from contact with biologically hazardous or toxic materials, do not attempt to force or draw liquid or gas through the valve's inlet or outlet ports.
  • Page 77 Figure 3–39: Tightening the shell nut Pump head Shell nut Valve Reinstall the outlet-tubing fitting on the side of the i Valve and minimally tighten it. Figure 3–40: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve Reattach the outlet-tubing fitting to the inlet manifold, and tighten it with your fingers to the extent possible.
  • Page 78 Figure 3–41: Reattaching outlet-tubing fitting Outlet-tubing fitting Inlet manifold Tighten the outlet-tubing fitting, on the side of the i Valve with your fingers, and then use the 1/4-inch open-end wrench to tighten the fitting an additional 1/6-turn, for existing fittings, or 3/4-turn, for new fittings. Figure 3–42: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold...

  • Page 79: Replacing The Primary Pump Head's Plunger And Seals

    Figure 3–43: Inserting i Valve connector into receptacle Valve connector Connector receptacle Knurled surface Power-on the solvent manager. 10. Prime the solvent manager (see Priming the solvent manager). 3.18 Replacing the primary pump head's plunger and seals Refer to the console online Help to help determine whether the primary pump head's seals require replacing.

  • Page 80: Moving The Plunger Backward

    • Seal removal tool • Sharp tool, such as a dental pick • Fluoropolymer O-ring • Methanol • Plunger (if replacing) • Plunger seal and plunger-seal spacer • Seal wash seal Replacing the plunger and seals in the primary pump head involves these steps: Flushing the solvent manager with nonhazardous solvent.

  • Page 81: Removing The I Valve Actuator

    3.18.2 Removing the i Valve actuator Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials. Warning: To avoid personal contamination from contact with biologically hazardous or toxic materials, do not attempt to force or draw liquid or gas through the valve's inlet or outlet ports.
  • Page 82 Figure 3–44: Removing i Valve connector from receptacle Valve connector Connector receptacle Knurled surface Loosen the finger-tight outlet-tubing fitting on the inlet manifold outlet. Figure 3–45: Outlet-tubing fitting on manifold Outlet-tubing fitting Inlet manifold Use the 1/4-inch open-end wrench to disconnect the inlet manifold outlet-tubing fitting on the side of the i Valve and remove the tubing.
  • Page 83 Figure 3–46: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve Use the 5/16-inch open-end wrench to loosen the shell nut, and then fully unscrew it. Figure 3–47: Loosening the shell nut Pump head Shell nut Valve Notice: To avoid damaging the i Valve actuator assembly when removing it, •...

  • Page 84: Removing The Primary Pump Head

    Figure 3–48: Removing actuator from pump head Bottom of pump head Valve actuator 3.18.3 Removing the primary pump head Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use.
  • Page 85 Figure 3–49: Location of seal-wash tubing Seal-wash tubing Seal-wash tubing Using a pliers, remove the drip wire from the head assembly. Figure 3–50: Removing drip wire Drip wire Pliers Using the 1/4-inch open-end wrench, disconnect the outlet tubing from the transducer. Figure 3–51: Location of outlet tubing August 8, 2016, 715005050 Rev.
  • Page 86 Transducer Outlet tubing Disconnect the pressure transducer cable from the bulkhead by squeezing on the tabs and pulling gently. Figure 3–52: Pressure transducer cable in connector Connector Tabs Using the T27 TORX driver, loosen the two head bolts 1/2-turn. Tip: The bolts are accessible from the front of the pressure transducer.

  • Page 87: Removing The Pump Head Plunger

    Figure 3–54: Support-plate bolts on primary pump head Support-plate bolts Figure 3–55: Removing primary pump head and support plate from actuator housing Support plate Pump head Plunger Stand the pump head upright on a clean surface. 3.18.4 Removing the pump head plunger Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials.
  • Page 88 Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. Required tools and materials • Chemical-resistant, powder-free gloves • Plunger removal tool To remove the pump head plunger: Warning: To avoid finger or hand lacerations from sharp-edged surfaces, use care when removing head-assembly components. Bending or twisting the sapphire piston shaft can cause it to fracture or splinter.

  • Page 89: Removing The Pump Head Seals

    3.18.5 Removing the pump head seals Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials. Notice: To avoid contaminating system components, wear clean, chemical-resistant, powder-free gloves when performing this procedure.
  • Page 90 Figure 3–59: Lifting pump head from support plate Pump head Seal-wash housing Support plate Remove the old seal-wash seal from the seal-wash housing, and discard the old seal. Figure 3–60: Location of seal-wash seal Seal-wash seal Seal-wash housing Using the smooth end of the seal removal tool, remove the plunger-seal spacer from the pump head.
  • Page 91 Figure 3–61: Location of plunger-seal spacer Plunger-seal spacer Insert seal removal tool here Notice: To avoid scratching any metal surfaces, use care when screwing the threaded end of the seal removal tool into the plunger seal. Taking care not to scratch any metal surfaces, screw the threaded end of the seal removal tool into the plunger seal, and carefully withdraw the seal from the pump head.

  • Page 92: Installing The New Pump Head Seals

    Figure 3–63: Location of O-ring O-ring 3.18.6 Installing the new pump head seals Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials.
  • Page 93 Figure 3–64: Installing O-ring O-ring Lubricate the new plunger seal with methanol, and use the smooth end of the seal removal tool to place it in the pump head. Figure 3–65: Placing plunger seal in pump head Plunger seal Seal removal tool Seal removal tool Plunger seal August 8, 2016, 715005050 Rev.
  • Page 94 Center the new plunger-seal spacer over the plunger seal so that the cross-side faces upward. Figure 3–66: Correct installation of plunger-seal spacer Plunger-seal spacer Orient the seal-wash housing so that the holes on its side align with the holes on the side of the pump head, and then guide it into place.
  • Page 95 Figure 3–68: Installing seal-wash seal in seal-wash housing Seal-wash seal Seal-wash housing Place the support plate on top of the pump head, ensuring that the round side of the plate is oriented toward the bottom side of the pump head. Figure 3–69: Placing support plate on pump head August 8, 2016, 715005050 Rev.

  • Page 96: Installing The New Pump-Head Plunger

    Round side of support plate Bottom side of pump head Holding the assembly together, use the T27 TORX driver to minimally tighten the two head bolts. Figure 3–70: Securing support plate to pump head Head bolts Support plate Recommendation: Replace the plunger whenever you replace the plunger seal. 3.18.7 Installing the new pump-head plunger Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when...
  • Page 97 To install the new pump head plunger: Flip the pump head assembly over and then lubricate the seals with methanol. Figure 3–71: Pump head seals Pump-head seals Carefully insert the plunger shaft into the pump head until the shaft is no longer visible. Requirement: Ensure that the shaft does not make contact with the support plate.

  • Page 98: Reinstalling The Primary Pump Head

    3.18.8 Reinstalling the primary pump head Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials. Notice: To avoid contaminating system components, wear clean, chemical-resistant, powder-free gloves when performing this procedure.
  • Page 99 Support plate Pump head Plunger Notice: To avoid damaging the plunger, alternately tighten the support plate screws 1/4-turn so that they are uniformly torqued. Hold the pump head assembly securely against the actuator housing, and then use the T27 TORX driver to tighten the support plate bolts securely. Figure 3–73: Support-plate bolts on primary pump head Support-plate bolts Alternately tighten the head bolts so that they are uniformly torqued.
  • Page 100 Figure 3–75: Reinstalling drip wire Drip wire Pliers Connect the pressure transducer cable to the bulkhead. Figure 3–76: Pressure transducer cable in connector Connector Tabs Reattach the outlet-tubing fitting to the transducer, tighten it with your fingers to the extent possible, and then use the 1/4-inch open-end wrench to tighten the fitting an additional 1/6- turn, for existing fittings, or 3/4-turn, for new fittings.

  • Page 101: Installing The I Valve Actuator

    Figure 3–77: Location of outlet tubing Transducer Outlet tubing Reinstall the seal-wash tubing on the barbed fittings on the seal wash housing. Figure 3–78: Location of seal-wash tubing Seal-wash tubing Seal-wash tubing 3.18.9 Installing the i Valve actuator Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials.
  • Page 102 Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. Required tools and materials • Chemical-resistant, powder-free gloves • 1/4-inch open-end wrench • 5/16-inch open-end wrench • i Valve actuator • i Valve cartridge (recommended) To install the i Valve actuator: Orient the i Valve assembly so that the cable exits from the left-hand side.
  • Page 103 Figure 3–80: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve Reattach the outlet-tubing fitting to the inlet manifold, and tighten it with your fingers to the extent possible. Requirement: Ensure that the outlet-tubing is fully engaged by raising the inlet manifold while attaching the outlet-tubing fitting.
  • Page 104 Figure 3–82: Inlet manifold outlet-tubing fitting Inlet manifold outlet-tubing fitting Inlet manifold Valve Align the white arrow on the i Valve connector with the white arrow on the receptacle, in the 12 o’clock position, and insert the connector into the receptacle. Figure 3–83: Inserting i Valve connector into receptacle Valve connector...

  • Page 105: Replacing The Accumulator Pump Head's Plunger And Seals

    3.19 Replacing the accumulator pump head's plunger and seals Refer to the console online Help to help determine whether the accumulator pump head's seals require replacing. Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use.

  • Page 106: Moving The Plunger Backward

    Installing the new pump head plunger. Reinstalling the pump head. Performing the solvent-manager leak test (see the console online Help). Tip: If the leak test results are unsatisfactory, pressurize the seals, to properly seat them. To do so, run the solvent manager at 96,527 kPa (965 bar, 14,000 psi) for 30 min, or run the leak test until results are satisfactory.
  • Page 107 To remove the accumulator pump head: Remove the seal-wash tubing, secured to the seal-wash housing by barbed fittings, using a tool or by pulling on the tubing as close to the pump head as possible. Figure 3–84: Location of seal-wash tubing Seal-wash tubing Seal-wash tubing Using the pliers, remove the drip wire from the head assembly.
  • Page 108 Figure 3–86: Location of outlet tubing Transducer Outlet tubing Using the 5/16-inch open-end wrench to hold the check-valve cartridge in place, disconnect the tubing connection from the check valve using the 1/4-inch open-end wrench. Figure 3–87: Location of check valve tubing connection Check valve Place 5/16-inch open-end wrench here Place 1/4-inch open-end wrench here...
  • Page 109 Figure 3–88: Pressure transducer cable in connector Connector Tabs Using the T27 TORX driver, loosen the 2 head bolts 1/2-turn. Tip: The bolts are accessible from the front of the pressure transducer. Figure 3–89: Head bolts on accumulator pump head Head bolts Notice: To avoid damaging the plunger, support the head from below as you...

  • Page 110: Removing The Pump Head Plunger

    Figure 3–90: Support-plate bolts on accumulator pump head Support-plate bolts Figure 3–91: Removing accumulator pump head and support plate from actuator housing Support plate Pump head Plunger Stand the pump head upright on a clean surface. 3.19.3 Removing the pump head plunger Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials.
  • Page 111 Recommendation: Replace the plunger seals when you replace the plunger. Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. Required tools and materials • Chemical-resistant, powder-free gloves • Plunger removal tool To remove the pump head plunger: Warning: To avoid finger or hand lacerations from sharp-edged surfaces, use care when removing head-assembly components.
  • Page 112 Recessed side of plunger removal tool 3.19.3.1 Removing the pump head seals Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials.
  • Page 113 Figure 3–95: Lifting pump head from support plate Pump head Seal-wash housing Support plate Remove the old seal-wash seal from the seal-wash housing, and discard the old seal. Figure 3–96: Location of seal-wash seal Seal-wash seal Seal-wash housing Using the smooth end of the seal removal tool, remove the plunger-seal spacer from the pump head.
  • Page 114 Figure 3–97: Location of plunger-seal spacer Plunger-seal spacer Insert seal removal tool here Notice: To avoid scratching any metal surfaces, use care when screwing the threaded end of the seal removal tool into the plunger seal. Taking care not to scratch any metal surfaces, screw the threaded end of the seal removal tool into the plunger seal, and carefully withdraw the seal from the pump head.
  • Page 115 Figure 3–99: Location of O-ring O-ring 3.19.3.2 Installing the new pump head seals Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials.
  • Page 116 Figure 3–100: Installing O-ring O-ring Lubricate the new plunger seal with methanol, and use the smooth end of the seal removal tool to place it in the pump head. Figure 3–101: Placing plunger seal in pump head Plunger seal Seal removal tool Seal removal tool Plunger seal August 8, 2016, 715005050 Rev.
  • Page 117 Center the new plunger-seal spacer over the plunger seal so that the cross-side faces upward. Figure 3–102: Correct installation of plunger-seal spacer Plunger-seal spacer Orient the seal-wash housing so that the holes on its side align with the holes on the side of the pump head, and then guide it into place.
  • Page 118 Figure 3–104: Installing seal-wash seal in seal-wash housing Seal-wash seal Seal-wash housing Place the support plate on top of the pump head, ensuring that the round side of the plate is oriented toward the bottom side of the pump head. Figure 3–105: Placing support plate on pump head August 8, 2016, 715005050 Rev.
  • Page 119 Round side of support plate Bottom side of pump head Holding the assembly together, use the T27 TORX driver to minimally tighten the two head bolts. Figure 3–106: Securing support plate to pump head Head bolts Support plate Recommendation: Replace the plunger whenever you replace the plunger seal. 3.19.3.3 Installing the new pump-head plunger Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when...
  • Page 120 To install the new pump head plunger: Flip the pump head assembly over and then lubricate the seals with methanol. Figure 3–107: Pump head seals Pump-head seals Carefully insert the plunger shaft into the pump head until the shaft is no longer visible. Requirement: Ensure that the shaft does not make contact with the support plate.
  • Page 121 3.19.3.4 Reinstalling the accumulator pump head Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous materials. Consult the Material Safety Data Sheets regarding the solvents you use. Additionally, consult the safety representative for your organization regarding its protocols for handling such materials. Notice: To avoid contaminating system components, wear clean, chemical-resistant, powder-free gloves when performing this procedure.
  • Page 122 Support plate Pump head Plunger Notice: To avoid damaging the plunger, alternately tighten the support plate screws 1/4-turn so that they are uniformly torqued. Hold the pump head assembly securely against the actuator housing, and then use the T27 TORX driver to tighten the support plate bolts securely. Figure 3–109: Support-plate bolts on accumulator pump head Support-plate bolts Alternately tighten the head bolts so that they are uniformly torqued.
  • Page 123 Figure 3–111: Reinstalling drip wire Drip wire Pliers Connect the pressure transducer cable to the bulkhead. Figure 3–112: Pressure transducer cable in connector Connector Tabs Using the 5/16-inch open-end wrench to hold the check-valve cartridge in place, reconnect the tubing connection to the check valve with the 1/4-inch open-end wrench. August 8, 2016, 715005050 Rev.
  • Page 124 Figure 3–113: Location of check valve tubing connection Check valve Place 5/16-inch open-end wrench here Place 1/4-inch open-end wrench here Reattach the outlet-tubing fitting to the transducer, tighten it with your fingers to the extent possible, and then use the 1/4-inch open-end wrench to tighten the fitting an additional 1/6- turn, for existing fittings, or 3/4-turn, for new fittings.

  • Page 125: Cleaning The Exterior Of The Equipment

    Figure 3–115: Location of seal-wash tubing Location of seal-wash tubing Location of seal-wash tubing 3.20 Cleaning the exterior of the equipment Warning: To avoid electric shock, • ensure that the electrical power to the equipment is interrupted; • when cleaning the surface of the equipment, apply water to a cloth, and then wipe the instrument or device.

  • Page 126: A Safety Advisories

    Heed all warnings when you install, repair, or operate any Waters instrument or device. Waters accepts no liability in cases of injury or property damage resulting from the failure of individuals to comply with any safety precaution when installing, repairing, or operating any of its instruments or devices.

  • Page 127: Specific Warnings

    (Risk of explosion.) A.1.1 Specific warnings A.1.1.1 Burst warning This warning applies to Waters instruments and devices fitted with nonmetallic tubing. Warning: To avoid injury from bursting, nonmetallic tubing, heed these precautions when working in the vicinity of such tubing when it is pressurized: •...

  • Page 128: Notices

    A.1.1.2 Biohazard warning The following warning applies to Waters instruments and devices that can process material containing biohazards, which are substances that contain biological agents capable of producing harmful effects in humans. Warning: To avoid infection with potentially infectious, human-sourced products, inactivated microorganisms, and other biological materials, assume that all biological fluids that you handle are infectious.

  • Page 129: Required Protection

    Use eye protection when performing this procedure. Requirement: Wear clean, chemical-resistant, powder-free gloves when performing this procedure. A.5 Warnings that apply to all Waters instruments and devices When operating this device, follow standard quality-control procedures and the equipment guidelines in this section.
  • Page 130 警告： 未經有關法規認證部門允許對本設備進行的改變或修改,可能會使使用者喪失操作 該設備的權利。 警告： 未经有关法规认证部门明确允许对本设备进行的改变或改装，可能会使使用者丧 失操作该设备的合法性。 경고: 규정 준수를 책임지는 당사자의 명백한 승인 없이 이 장치를 개조 또는 변경할 경우, 이 장치를 운용할 수 있는 사용자 권한의 효력을 상실할 수 있습니다. 警告: 規制機関から明確な承認を受けずに本装置の変更や改造を行うと、本装置のユーザーとして の承認が無効になる可能性があります。 Warning: Use caution when working with any polymer tubing under pressure: •...
  • Page 131 Warnung: Bei der Arbeit mit Polymerschläuchen unter Druck ist besondere Vorsicht angebracht: • In der Nähe von unter Druck stehenden Polymerschläuchen stets Schutzbrille tragen. • Alle offenen Flammen in der Nähe löschen. • Keine Schläuche verwenden, die stark geknickt oder überbeansprucht sind. •...
  • Page 132 圧力のかかったポリマーチューブを扱うときは、注意してください。 • 加圧されたポリマーチューブの付近では、必ず保護メガネを着用してください。 • 近くにある火を消してください。 • 著しく変形した、または折れ曲がったチューブは使用しないでください。 • 非金属チューブには、テトラヒドロフラン(THF)や高濃度の硝酸または硫酸などを流さないでくださ い。 • 塩化メチレンやジメチルスルホキシドは、非金属チューブの膨張を引き起こす場合があり、その場 合、チューブは極めて低い圧力で破裂します。 This warning applies to Waters instruments fitted with nonmetallic tubing. This warning applies to instruments operated with flammable solvents. August 8, 2016, 715005050 Rev. C Page 132...

  • Page 133: Warnings That Address The Replacing Of Fuses

    Warning: The user shall be made aware that if the equipment is used in a manner not specified by the manufacturer, the protection provided by the equipment may be impaired. Avertissement : L’utilisateur doit être informé que si le matériel est utilisé d’une façon non spécifiée par le fabricant, la protection assurée par le matériel risque d’être défectueuses.
  • Page 134 Avertissement : pour éviter tout risque d'incendie, remplacez toujours les fusibles par d'autres du type et de la puissance indiqués sur le panneau à proximité du couvercle de la boite à fusible de l'instrument. Warnung: Zum Schutz gegen Feuer die Sicherungen nur mit Sicherungen ersetzen, deren Typ und Nennwert auf den Tafeln neben den Sicherungsabdeckungen des Geräts gedruckt sind.

  • Page 135: Electrical Symbols

    警告： 為了避免火災，更換保險絲時，應使用「維護步驟」章節中「更換保險絲」所指 定之相同類型與規格的保險絲。 警告： 为了避免火灾，应更换“维护步骤”一章的“更换保险丝”一节中介绍的相同类 型和规格的保险丝。 경고: 화재의 위험을 막으려면 유지관리 절차 단원의 “퓨즈 교체” 절에 설명된 것과 동 일한 타입 및 정격의 제품으로 퓨즈를 교체하십시오. 警告: 火災予防のために、ヒューズ交換ではメンテナンス項目の「ヒューズの交換」に記載されているタ イプおよび定格のヒューズをご使用ください。 A.7 Electrical symbols The following electrical symbols and their associated statements can appear in instrument manuals and on an instrument’s front or rear panels.

  • Page 136: Handling Symbols

    A.8 Handling symbols The following handling symbols and their associated statements can appear on labels affixed to the packaging in which instruments, devices, and component parts are shipped. Symbol Description Keep upright! Keep dry! Fragile! Use no hooks! Upper limit of temperature Lower limit of temperature Temperature limitation August 8, 2016, 715005050 Rev.

  • Page 137: B Specifications

    Specifications The reproducibility of the specifications presented in this document depends on the conditions in individual laboratories. Contact the Waters Technical Service organization for additional information about specifications. B.1 QSM and bioQSM physical specifications Attribute Specification Height (with feet) 23.8 cm (9.4 in) with 2.2 cm (0.875 in) feet Width 34.3 cm (13.5 in)

  • Page 138: Qsm And Bioqsm Input/Output Specifications

    Attribute Specification Overvoltage category Pollution degree Normal (IPXO) Moisture protection Line voltages, nominal Grounded AC Voltage range 100 to 240 Vac Frequency 50 to 60 Hz Maximum power draw 360 VA a. Protection Class I – The insulating scheme used in the instrument to protect from electrical shock. Class I identifies a single level of insulation between live parts (wires) and exposed conductive parts (metal panels), in which the exposed conductive parts are connected to a grounding system.

  • Page 139: Qsm And Bioqsm Performance Specifications

    • Flow rate: 0.5 mL/min • Sample mix: alkylphenone mix (5.0 µL injection volume) • Column: ACQUITY UPLC BEH C , 1.7 µm, 2.1 × 50 mm • Column temperature: 35 °C ±0.3 °C • Detector: UV, 254 nm wavelength Composition ripple <1.0 mAU (<0.1 mAU with optional 250-µL mixer), with i...
  • Page 140 • Flow rate: 0.5 mL/min • Sample mix: alkylphenone mix (5.0 µL injection volume) • Column: ACQUITY UPLC BEH C , 1.7 µm, 2.1 × 50 mm • Column temperature: 35 °C ±0.3 °C • Detector: UV, 254 nm wavelength...

  • Page 141: Qsm And Bioqsm Wetted Materials Of Construction

    B.6 QSM and bioQSM wetted materials of construction Description Specification 316L stainless steel, DLC, fluoroelastomer, fluoropolymer, Nitronic 60, PEEK, PEEK blend, PPS, ruby, sapphire, titanium alloy, UHMWPE blend, zirconia bioQSM DLC, fluoroelastomer, fluoropolymer, Nitronic 60, PEEK, PEEK blend, PPS, ruby, sapphire, titanium, UHMWPE blend, zirconia August 8, 2016, 715005050 Rev.

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