GE Biacore X100 Operating Instructions Manual
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GE Biacore X100 Operating Instructions Manual

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Biacore
™
X100
Operating Instructions
Original instructions

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Summary of Contents for GE Biacore X100

  • Page 1 Biacore ™ X100 Operating Instructions Original instructions...

  • Page 2: Table Of Contents

    Inserting a sensor chip ........................Setting the analysis temperature ....................Preparing and loading samples and reagents ............... Starting a run ............................Post-run procedures ........................... Maintenance ......................Maintenance preparations ....................... Maintenance summary ........................Cleaning ..............................Component maintenance ........................ Biacore X100 Operating Instructions 28961142 AD...
  • Page 3 Calibration ..............................Storage ..............................Troubleshooting ....................Instrument related problems ......................Other problems ............................Reference information ..................Specifications ............................Chemical resistance ..........................Health and Safety Declaration Forms ..................Appendix A Software tool texts ................Index ........................Biacore X100 Operating Instructions 28961142 AD...

  • Page 4: Introduction

    1 Introduction Introduction About this chapter This chapter contains important user information, descriptions of safety notices, regula- tory information, intended use of the Biacore X100 system, and lists of associated docu- mentation. In this chapter Section See page 1.1 About this manual 1.2 Important user information...

  • Page 5: About This Manual

    Software items are identified in the text by bold italic text. A colon separates menu levels, thus File:Open refers to the Open command in the File menu. Hardware items are identified in the text by bold text (for example, Power). Biacore X100 Operating Instructions 28961142 AD...

  • Page 6: Important User Information

    Intended use of the product Biacore X100 is a system for real-time label-free analysis of molecular interactions in laboratory research. Biacore X100 is intended for research use only and shall not be used for diagnostic purposes in any clinical or in vitro procedures.
  • Page 7 Notes and tips Note: A note is used to indicate information that is important for trouble-free and optimal use of the product. Tip: A tip contains useful information that can improve or optimize your procedures. Biacore X100 Operating Instructions 28961142 AD...

  • Page 8: Regulatory Information

    1 Introduction 1.3 Regulatory information Regulatory information Introduction This section lists the regulations and standards that apply to the Biacore X100 system. Manufacturing information The table below summarizes the required manufacturing information. Requirement Information Name and address of manufacturer GE Healthcare Bio-Sciences AB, Björkgatan 30, SE 751 84 Uppsala, Sweden...

  • Page 9: Eu Directives

    • used according to the Operating Instructions or user manuals, and • used in the same state as it was delivered from GE, except for alterations described in the Operating Instructions or user manuals. Biacore X100 Operating Instructions 28961142 AD...

  • Page 10: Eurasian Customs Union

    GE Healthcare Life Sciences Presnenskaya nab., 10C, 12th floor RU-123 317 Moscow, Russian Federation Telephone 1: + 7 495 411 9714 Fax nr: + 7 495 739 6932 Email: LSrus@ge.com Biacore X100 Operating Instructions 28961142 AD...

  • Page 11: Regulations For Usa And Canada

    1.3.3 Regulations for USA and Canada Introduction This section describes the regulations that apply to the Biacore X100 instrument in the USA and Canada. NRTL certification This symbol indicates that the product has been certified by Intertek, which is a US Oc- cupational Safety and Health Administration Nationally Recognized Testing Laboratory (NRTL).

  • Page 12: Korean Regulatory Information

    When used in a residential environment, there is a concern of radio interference. 주의사항 A급 기기 (업무용 방송통신 기자재) 이 기기는 업무용환경에서 사용할 목적으로 적합성평가를 받은 기기 로서 가정용 환경에서 사용하는 경우 전파간섭의 우려가 있습니 다. Biacore X100 Operating Instructions 28961142 AD...

  • Page 13: Other Regulations And Standards

    1 Introduction 1.3 Regulatory information 1.3.5 Other regulations and standards 1.3.5 Other regulations and standards Introduction This section describes the standards that apply to the Biacore X100 system. Environmental conformity This product conforms to the following environmental requirements. Requirement Title 2012/19/EU...
  • Page 14 Regulatory compliance of connected equipment Any equipment connected to Biacore X100 should meet the safety requirements of IEC/EN/UL/CSA 61010-1, IEC/EN/UL/CSA 60950-1, or other relevant national safety reg- ulations and standards. The equipment should be installed and used according to the manufacturer's instructions.

  • Page 15: Associated Documentation

    GE. User documentation Biacore X100 system together with operation of the Control and Evaluation Software is described in full in the Biacore X100 Handbook. Sensor surface preparation and general methodology for Biacore applications are de- scribed in the Biacore Sensor Surface Handbook and the Biacore Assay Handbook respec- tively.

  • Page 16: Safety Instructions

    In this chapter Section See page 2.1 Safety precautions 2.2 Labels 2.3 Emergency procedures 2.4 Recycling information 2.5 Declaration of Hazardous Substances (DoHS) Biacore X100 Operating Instructions 28961142 AD...

  • Page 17: Safety Precautions

    2.1 Safety precautions Safety precautions Introduction Biacore X100 is powered by mains voltage and handles materials that can be hazardous. Before installing, operating or maintaining the system, you must be aware of the hazards described in this manual. Follow the instructions to avoid injury to the operator or other personnel, damage to samples or other substances handled by the equipment, to the product, or to other equipment in the area.
  • Page 18 Protective ground. The product must always be connected to a grounded power outlet. WARNING Use only mains cables supplied or approved by GE. WARNING Do not block the rear or side panels of the instrument. The power switch must always be easy to access. The power cord must always be easy to disconnect.
  • Page 19 2.1 Safety precautions Flammable liquids and explosive environment WARNING The Biacore X100 system is not intended for use in locations with explosion risks or fire hazards. WARNING Liquids marked as flammable must not be used as running buffer or pumped reagents. Any buffer or reagent containing flammable substances must be placed in properly capped vials in the sample rack.
  • Page 20 2 Safety instructions 2.1 Safety precautions CAUTION Biacore X100 systems that are used with toxic or hazardous sub- stances shall be marked in accordance with local laws and regula- tions. CAUTION Pinch risk. Take care that fingers are not trapped by moving parts on the instrument.
  • Page 21 Make sure that the waste container has sufficient space for maxi- mum waste volume when the equipment is left unattended. CAUTION Ensure that all fluidic tubes are secured and properly connected or sealed at both ends before, during and after operation. Biacore X100 Operating Instructions 28961142 AD...
  • Page 22 GE. Do not open any covers or replace any parts unless specifically stated in the user documentation. WARNING The Biacore X100 system contains mains voltage of up to 240 V AC. Disconnect mains cord before replacing fuses. Do not remove instrument covers.

  • Page 23: Labels

    The following illustration shows an example of the system label that is attached to the Biacore X100 instrument. The system label identifies the product and shows electrical data and regulatory compliance. The label is located on the right-hand side panel of the instrument.
  • Page 24 Eurasian Customs Union. This symbol indicates that Biacore X100 has been certified by a Nationally Recognized Testing Laboratory (NRTL). This product Conforms to UL 61010-1, and is Certified to CAN/CSA- C22.2 No.
  • Page 25 2 Safety instructions 2.2 Labels Symbol/text Meaning Voltage Electrical requirements: Frequency Mains voltage (VAC • Max Power Frequency (Hz) • Maximum power (VA) • Biacore X100 Operating Instructions 28961142 AD...

  • Page 26: Emergency Procedures

    Emergency procedures Introduction This section describes how to shut down the Biacore X100 system in an emergency sit- uation, and the procedure for restarting the Biacore X100 system. The section also describes the result in the event of power failure.
  • Page 27 Turn on mains power if it is switched off and check that the instrument starts normally. If you need to clean the liquid handling system, eject the sensor chip and insert a maintenance chip. See Section 6.3 Cleaning, on page 66 for further instructions. Biacore X100 Operating Instructions 28961142 AD...

  • Page 28: Recycling Information

    When taking the product out of service, the different materials must be separated and recycled according to national and local environmental regulations. Biacore X100 contains a lithium backup battery, which must not be disposed of in fire. Disposal of batteries Waste batteries and accumulators must not be disposed as unsorted municipal waste and must be collected separately.

  • Page 29: Declaration Of Hazardous Substances (Dohs)

    Periodic replacement of those consumables or parts to maintain the declared EFUP shall be done in accordance with the Product Maintenance Procedures. This product must not be disposed of as unsorted municipal waste, and must be collected separately and handled properly after decommissioning. Biacore X100 Operating Instructions 28961142 AD...
  • Page 30 Indicates that this hazardous substance contained in at least one of the homogeneous materials used for this part is above the limit requirement in GB/T 26572 Data listed in the table represents best information available at the time of publication. • Biacore X100 Operating Instructions 28961142 AD...

  • Page 31: System Description

    3 System description System description About this chapter This chapter gives an overview of the Biacore X100 system, and a brief description of its function. In this chapter Section See page 3.1 Biacore X100 instrument 3.2 Indicators and switches 3.3 Sensor chip 3.4 Control system...

  • Page 32: Biacore X100 Instrument

    The main parts of the instrument are identified below. Part Function Status indicators Lower front door with pump compartment and optional degasser (included in Biacore X100 Plus Package) behind Buffer tubes Buffer bottle Buffer tray Upper front door with sensor chip port behind...
  • Page 33 If this happens, disconnect the instrument from the mains power and call your local service representative. CAUTION Waste tubes and containers shall be secured and sealed to prevent accidental spillage. Biacore X100 Operating Instructions 28961142 AD...
  • Page 34 The rack moves at times during the run and the needle may be destroyed if the rack is prevented from moving. Do not attempt to rotate the rack by hand in the instrument. Biacore X100 Operating Instructions 28961142 AD...
  • Page 35 SERVICE Part Function Computer ports Mains switch Fuse compartment Mains inlet Note: For warning texts, see Section 6.5 Replacing the mains fuses, on page Biacore X100 Operating Instructions 28961142 AD...

  • Page 36: Indicators And Switches

    Lit when a run is in progress. Mains power switch The mains power connector and switch is located on the mains input panel, at the rear right of the instrument (see Connections, on page 35). Biacore X100 Operating Instructions 28961142 AD...

  • Page 37: Sensor Chip

    Do not remove the sensor chip from the cassette. The illustration below shows the sensor chip separate from the cassette for illustration purposes. Part Function Frame Gold-coated glass slide Cassette Biacore X100 Operating Instructions 28961142 AD...

  • Page 38: Control System

    Biacore X100 Evaluation Software is a stand-alone software for evaluation of results obtained from Biacore X100. The software is normally installed on the same computer as the Biacore X100 Control Software, although connection to the instrument is not re- quired for using Biacore X100 Evaluation Software.

  • Page 39: Installation

    About this chapter This chapter describes site requirements and preparations necessary to perform before installation of the Biacore X100 system. In addition, instructions are included for moving the Biacore X100 system within the lab or to another building. NOTICE Biacore X100 is prepared and installed by GE personnel. Contact GE if you require re-installation at a new site.

  • Page 40: Site Requirements

    Space is also required for the PC beside the instrument. The laboratory bench must be stable and able to support the weight of the instrument. Biacore X100 Operating Instructions 28961142 AD...
  • Page 41 Protective ground. The product must always be connected to a grounded power outlet. WARNING Use only mains cables supplied or approved by GE. WARNING Do not block the rear or side panels of the instrument. The power switch must always be easy to access. The power cord must always be easy to disconnect.
  • Page 42 Pollution degree 2 ment Avoid placing the system adjacent to heaters or air conditioners. Condensation may occur in the sample compartment at high ambient humidity. This is normal and does not indicate any malfunction. Biacore X100 Operating Instructions 28961142 AD...

  • Page 43: Unpacking, Assembly And Transport

    Biacore X100 requires no special assembly other than that performed by GE personnel during installation. Transport To avoid damage, the optical unit in Biacore X100 must be secured before transport over more than limited distances within the laboratory. Contact GE for assistance. CAUTION Heavy object.

  • Page 44: Connections

    INLET connector on the rear panel (see Connections, on page 35). Connect the other end to a mains outlet with protective earth. Check that any mains voltage selectors on the PC and peripheral equipment are set correctly. Biacore X100 Operating Instructions 28961142 AD...
  • Page 45 Install the PC and peripheral equipment according to the respective instruc- tion manuals. WARNING Do not block the rear or side panels of the instrument. The power switch must always be easy to access. The power cord must always be easy to disconnect. Biacore X100 Operating Instructions 28961142 AD...

  • Page 46: Operation

    Safety precautions WARNING Always wear appropriate protective clothing and equipment during operation and maintenance of the Biacore X100 system. Use re- quired safety equipment when handling hazardous substances. WARNING Do not use any accessories not supplied or recommended by GE.
  • Page 47 Waste liquids may contain hazardous or flammable substances. Take appropriate precautions to avoid spillage of hazardous waste. CAUTION Biacore X100 systems that are used with toxic or hazardous sub- stances shall be marked in accordance with local laws and regula- tions.
  • Page 48 5 Operation CAUTION Accidental breakage of glass bottles may leave sharp fragments and splinters that can cause cuts and abrasions. Biacore X100 Operating Instructions 28961142 AD...

  • Page 49: Overview

    5 Operation 5.1 Overview Overview The typical workflow for performing a run in Biacore X100 is shown in the table below. Some analyses may require several runs to complete the experiment. Stage Description More information Create a workflow or wizard template, Biacore X100 Handbook or software or use a previously saved workflow.

  • Page 50: Starting The Instrument

    Start the instrument from shutdown NOTICE If you have the Biacore X100 Plus Package, always keep the buffer tubes in liquid when the instrument is powered on to prolong the life of the degasser. Follow the steps below to start the system from shutdown.
  • Page 51 Action In the login-dialog, enter your user name and password and click OK. (Your user name and password are provided by your Biacore X100 administrator.) If you need to select a different database connection, click Options>>. The default setup is This machine.
  • Page 52 Follow the steps below to start from standby. Step Action Start Biacore X100 Control Software if it is not already running. In the login-dialog, enter your user name and password and click OK. (Your user name and password are provided by your Biacore X100 administrator.) If you need to select a different database connection, click Options>>.

  • Page 53: Preparing, Loading And Changing Buffers

    If the instrument is equipped with the degasser provided with Biacore X100 Plus Package, you do not need to degas the water. Always use buffer, fresh for the day and filtered through a 0.22 µm filter to remove par- ticles.

  • Page 54: Inserting A Sensor Chip

    Pull out the chip slide. If required, remove the old chip. Insert the chip with the text on the upper side and the arrow pointing into the instrument. Push the chip slide all the way in. Biacore X100 Operating Instructions 28961142 AD...
  • Page 55 Close the front door and check that the buffer tubes are placed in a bottle of buffer. Complete in the information in the Dock Chip dialog and click Dock Chip. The chip is docked and the standby flow of buffer over the chip starts automatically. Biacore X100 Operating Instructions 28961142 AD...

  • Page 56: Setting The Analysis Temperature

    The analysis temperature is fixed at 25°C in the standard instrument. With the optional Biacore X100 Plus Package, the analysis temperature can be set to 4°C to 40°C (maximum 10°C below ambient temperature).

  • Page 57: Preparing And Loading Samples And Reagents

    Make sure there are no visible air bubbles in the tubes. Cap the vials to avoid evaporation during the run. Use only caps supplied for this purpose by GE. Fill the 4 mL vial with distilled water. Always use fresh water filtered through a 0.22 µm filter to remove particles.
  • Page 58 Lift out the rack and place the sample and reagent vials and the water vial according to the rack position list. Insert the rack in the sample compartment and make sure it sits properly on the rack base. Click OK in the Load Samples dialog. Biacore X100 Operating Instructions 28961142 AD...

  • Page 59: Starting A Run

    Starting a run Runs are programmed and started from a workflow, an application wizard or via a manual run. Details of how to program a run may be found in the Biacore X100 Handbook and in the integrated software support.

  • Page 60: Post-Run Procedures

    Prepare the system for standby. used within 7 days If the instrument will not Perform a shutdown. be used for more than 7 days Section 6.7 Storage, on page 74 for details of these procedures. Biacore X100 Operating Instructions 28961142 AD...

  • Page 61: Maintenance

    All service and repairs, with the exception of operations explicitly described in the user documentation, must be carried out by per- sonnel authorized by GE. Do not open any covers or replace any parts unless specifically stated in the user documentation.
  • Page 62 6 Maintenance In this chapter Section See page 6.1 Maintenance preparations 6.2 Maintenance summary 6.3 Cleaning 6.4 Component maintenance 6.5 Replacing the mains fuses 6.6 Calibration 6.7 Storage Biacore X100 Operating Instructions 28961142 AD...

  • Page 63: Maintenance Preparations

    Make sure that the BIAmaintenance Kit is available before starting maintenance proce- dures. Regular maintenance of Biacore X100 is essential for reliable results. It is important to keep the instrument free from contamination such as microbial growth and adsorbed proteins in the liquid handling system.
  • Page 64 6 Maintenance 6.1 Maintenance preparations NOTICE Do not use BIAdesorb solution 1 at analysis temperatures below 20°C. BIAdesorb solution 1 precipitates at low temperatures. Biacore X100 Operating Instructions 28961142 AD...

  • Page 65: Maintenance Summary

    For some applications, a coating of protein on the flow system walls helps to give reproducible results, and the first few cycles after Desorb may be unreliable. If you observe this behavior, run Desorb when you change your protein system rather than once a week. Biacore X100 Operating Instructions 28961142 AD...

  • Page 66: Cleaning

    Copy the form you need from Section 8.3 Health and Safety Declaration Forms, on page 88 or print it from the PDF file available on the User Documentation CD. Biacore X100 Operating Instructions 28961142 AD...
  • Page 67 If necessary, clean the cover of the instrument with a moist cloth. Use water or a mild detergent. The buffer tray and the waste tray can be removed for cleaning. If salt residues or proteins have accumulated on the buffer bottle cap, clean the cap in deionized water. Biacore X100 Operating Instructions 28961142 AD...
  • Page 68 Use Sensor Chip Maintenance or a used chip for the procedure. The solutions used may damage the ligand on sensor chips used for assays. Solutions for Desorb and Desorb and Sanitize are provided in the Maintenance Kit. Biacore X100 Operating Instructions 28961142 AD...
  • Page 69 Run the maintenance tool Normalize to normalize the detector response for all flow cells. NOTICE Run Normalize with the sensor chip that will be used for the run. Do not use Sensor Chip Maintenance for this purpose. Biacore X100 Operating Instructions 28961142 AD...

  • Page 70: Component Maintenance

    Part Function Peristaltic pump Peristaltic pump tube fittings Degasser tube fittings (only included with Biacore X100 Plus Package) Syringe pump tube fittings Syringe pump Syringe pump barrel (below the plunger) Syringe pump plunger fitting...

  • Page 71: Replacing The Mains Fuses

    Follow the steps below to replace the mains fuses. Step Action Turn off the power to the Biacore X100 instrument. Disconnect the mains cord from the mains power inlet. Insert a small screwdriver under the tab on the fuse drawer cover.
  • Page 72 6.5 Replacing the mains fuses Step Action Prise open the fuse drawer cover. Replace both fuses. See the instrument product label for fuse ratings. Close the fuse drawer cover and reconnect the mains supply. Biacore X100 Operating Instructions 28961142 AD...

  • Page 73: Calibration

    The peristaltic pump is calibrated with the System check and pump calibration tool from the Tools:More Tools menu. Needle positioning is calbrated with the Replace needle tool from the Tools:More Tools menu. All other calibration of Biacore X100 is performed by GE. Biacore X100 Operating Instructions 28961142 AD...

  • Page 74: Storage

    Leave the system in standby mode if it is to be used within the next 7 days. Biacore X100 is automatically placed in standby mode after the end of each run. In standby mode the instrument maintains a continuous low flow of buffer or water from the left hand bottle through the flow system to prevent accumulation of buffer residues and to preserve the ligand on the chip.
  • Page 75 When instructed, open the lower front door and open the cover of the peri- staltic pump to release the clamping of the pump tube. Exit from Biacore X100 Control Software if it is still running. Remove the bottles, and the buffer bottle cap assembly. Clean the bottle trays if required.
  • Page 76 Temperature: preferably room temperature, not below freezing • Relative humidity: non-condensing, preferably low humidity Contact GE if you are uncertain of storage conditions. After storage, start up the system as described in Start the instrument from shutdown, on page 50 and run System check and pump calibration from the Tools:More Tools menu before performing any experiments.

  • Page 77: Troubleshooting

    Instructions, and clean and maintain the instrument regularly as described in Chapter 6 Maintenance, on page 61. If you are experiencing problems that you cannot correct, contact your local service representative. In this chapter Section See page 7.1 Instrument related problems 7.2 Other problems Biacore X100 Operating Instructions 28961142 AD...

  • Page 78: Instrument Related Problems

    If the needle is damaged, check the following: Possible cause Action Unsuitable caps have been used Ensure that only caps supplied by GE are used on the vials. to cap the 1.5 mL sample and reagent vials. Never cap the water vial.
  • Page 79 If any test failed, perform the action(s) according to the table below and then repeat the System Check and Pump Calibration. If the problem persists, contact your local GE service representative. Use the table below to evaluate the results of the System check and pump calibration procedure.
  • Page 80 The cover of the peri- Close the cover. staltic pump is not prop- erly closed. The flow system is leak- Check for leaks (CheckLeaks). ing. Biacore X100 Operating Instructions 28961142 AD...
  • Page 81 Other instrument-related problems Unexpected detection results may appear if there are dust or other particles on the sensor chip surface. Never remove the sensor chip from its protective cassette. Biacore X100 Operating Instructions 28961142 AD...

  • Page 82: Other Problems

    Assay-related problems The Support Navigator in the software provides help on assay related problems. If you cannot solve your problems with the information provided, contact your local application support specialist. Biacore X100 Operating Instructions 28961142 AD...

  • Page 83: Reference Information

    8 Reference information Reference information About this chapter This chapter lists the technical specifications of Biacore X100. The chapter also includes a chemical resistance guide and Health and Safety Declaration forms for service. In this chapter Section See page 8.1 Specifications 8.2 Chemical resistance...

  • Page 84: Specifications

    600 × 530 × 575 mm (see also Space requirements, on page Net weight 47 kg Supply voltage Autorange 100 to 240 V~, protective earthing Maximum voltage fluctuation ± 10% from the nominal voltage Frequency 50/60 Hz Biacore X100 Operating Instructions 28961142 AD...
  • Page 85 Ambient temperature range 18°C to 33°C Ambient humidity ≤ 80% RH Analysis temperature Without Biacore X100 Plus Package: 25°C. With Biacore X100 Plus Package: 4°C to 40°C, max. 10°C below ambient tempera- ture System controller and software Parameter Value PC operating system Microsoft Windows 7 or 10 Professional (64-bit) ®...
  • Page 86 8 Reference information 8.1 Specifications Liquid containers Parameter Value Running buffer 500 mL, screw cap Waste 50 mL, screw cap Biacore X100 Operating Instructions 28961142 AD...

  • Page 87: Chemical Resistance

    Biacore X100 components. Regarding exposure to solutions not covered by these guidelines, contact your GE representative for recommendations. The flow system and sensor chip are the only parts of Biacore X100 that come into contact with solutions. The guidelines in this section relate to tubing and connectors, selector valves, connector block, IFC and sensor chip.

  • Page 88: Health And Safety Declaration Forms

    Service Ticket #: To make the mutual protection and safety of GE service personnel and our customers, all equipment and work areas must be clean and free of any hazardous contaminants before a Service Engineer starts a repair. To avoid delays in the servicing of your equipment, please complete this checklist and present it to the Service Engineer upon arrival.
  • Page 89 To make sure the mutual protection and safety of GE personnel, our customers, transportation personnel and our environment, all equipment must be clean and free of any hazardous contaminants before shipping to GE. To avoid delays in the processing of your equipment, please complete this checklist and include it with your return.

  • Page 90: Appendix A Software Tool Texts

    Appendix A Software tool texts The on-screen instructions in the maintenance, test and service software tools are given in English. Translations to other languages are provided in the local language versions of these Operating Instructions. Biacore X100 Operating Instructions 28961142 AD...

  • Page 91: Index

    Important user information, 6 precautions, 17 Inserting asensor chip, 54 Safety notices, 7 Instrument overview, 32 Sample compartment, 34 Instrument problems, 78 Sample rack Instrument startup, 50 loading, 57 Intended use, 6 Samples, 57 Sensor chip, 37 Biacore X100 Operating Instructions 28961142 AD...
  • Page 92 System check, 70, 79 Software problems, 82 Space requirements, 40 Specifications, 84 Temperature control, 56, 81 Standards, 13 Typographical conventions, 5 Standby, 74 Start a run, 59 Starting the instrument, 50 Workflow, 49 Status indicators, 36 Biacore X100 Operating Instructions 28961142 AD...
  • Page 93 All goods and services are sold subject to the terms and conditions of sale of 751 84 Uppsala the company within GE Healthcare which supplies them. A copy of these terms and conditions is available on request. Contact your local GE Healthcare repre- Sweden sentative for the most current information.

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