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Chemyx Fusion 4000 User Manual

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FUSION 4000 & 6000
USER MANUAL

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  • Page 1 FUSION 4000 & 6000 USER MANUAL...

  • Page 2: Table Of Contents

    EU Declaration of Conformity (DoC)........................6 General Description...............................7 Warranty and Repair Information........................9 Warranty Information..........................9 Repair Facilities and Parts........................10 Dead Pixel Policy............................10 Serial Numbers............................10 Calibrations............................10 Product Overview..............................11 Principle of Operation..........................11 Controlled Elements..........................12 Specifications...............................15 Pump Setup................................17 Powering On/Off the Pump........................17 Loading a Syringe.............................18 Adjusting the Safety Nut/Stall Rod......................21 Pump Operation............................22 Mode Selection Screen..........................24 Pressure & Temperature Settings (Fusion 6000 only)...............25 Basic Mode................................26...
  • Page 3 Syringe Selection.............................32 Total Steps..............................33 Loop All..............................33 Sub-Loops............................33 Flow-Rate Units............................34 Step Parameters..............................34 Volume............................35 Pump Control...............................36 System Settings..............................39 Pump Control by Computer..........................41 Cable Requirements............................41 Connecting ................................41 COM Port Settings............................42 Pump Commands..............................43 Chemyx Pump Controller Programs.........................48 Pump Maintenance.............................49 Lubricating the Pump..........................49 Lubrication Instructions.........................49 Approved Lubricants..........................49 Pump Accessories..............................50...
  • Page 4 Appendices..............................52 Appendix A: Syringe Volume/Diameter Reference................52 Appendix B: Available Parts........................56 Appendix C: Contact Information......................57...
  • Page 5 INTELLECTUAL PROPERTY All Intellectual Properties, as defined below, owned by or which is otherwise the property of Chemyx Inc. or its suppliers relating to the Chemyx syringe pumps, including but not limited to, accessories, parts or software relating thereto (Chemyx Syringe Pumps), are proprietary to federal and state laws, and international treaty provisions. Intellectual Property includes but is not limited to, inventions (patentable or unpatentable), patents, trade secrets, copyrights, software, firmware, computer programs, and related documentation and other works of authorship. Moreover, you agree that you will not, and will not attempt to, modify, prepare derivative works of, reverse engineer, disassemble the Chemyx syringe pumps, decompile or otherwise attempt to create source code from the related software/firmware. No title to or ownership in Intellectual Property is transferred to you. All applicable rights of the Intellectual Property shall remain with Chemyx and its suppliers.

  • Page 6: Eu Declaration Of Conformity (Doc)

    Details of these special measures and limitations to use are available on request, and are also contained in the product manuals. The PDF version of the latest DoC can be downloaded at www.chemyx.com/support...

  • Page 7: General Description

    CHEMYX PRODUCTS ARE NOT APPROVED FOR CLINICAL USE ON HUMANS. USE PROPER POWER SUPPLY Chemyx is not responsible for the use of power supplies outside the stated electrical specifications or failure to switch the power converter from 220V to 110 V while in the 220V environment or vice versa.

  • Page 8: Warranty And Repair Information

    Warranty and Repair Information Warranty Information Chemyx provides a two-year warranty from the shipment date for its pumps against defects in materials and workmanship. Chemyx will repair any product that proves defective during its stated warranty period. The foregoing warranty will not apply to damage resulting from: Improper or inadequate maintenance or operation.

  • Page 9: Repair Facilities And Parts

    Although the pump is highly accurate, syringes of different materials can attribute significant volume errors. Typically, these errors can range from 1% for glass syringes to 5% for plastic syringes. Chemyx is not responsible for errors generated from syringes.

  • Page 10: Product Overview

    Product Overview The Chemyx Fusion product line serve a wide variety of applications. The Chemyx Fusion 4000 is configured with two independently controlled syringe pump channels while the Chemyx Fusion 6000 is a high-pressure syringe pump designed for dosing viscous solutions, and semi-solid material injections against pressure. The units’ flexibility with syringe types and sizes and an advanced software interface make this high-pressure syringe pumps integrable into any operation or laboratory work flow.

  • Page 11: Controlled Elements

    The Fusion 4000 has two independent syringe channels, while the Fusion 6000 has one large syringe channel. The Fusion 4000 has a safety collar while the Fusion 6000 has a stall rod to help protect the integrity of syringes by keeping the pusher block from pushing on a completely depressed syringe.
  • Page 12 The physical pump control keys are used to start, pause, and stop pump activity. The power LED and pump-control LEDs allow users to easily discern whether the pump is on and whether it is currently running, paused, or stopped. +1 281-277-5499 | www.chemyx.com...
  • Page 13 FUSION 4000 SPECIFIC COMPONENTS Flange Retaining Bracket The Fusion 4000 is capable of both infusion and withdrawal with two independently controlled pumps. The Fusion 4000 uses adjustable retaining brackets on the pusher block and the syringe holder block, that keep each individual syringe channel in place during infusion and withdrawal.

  • Page 14: Specifications

    Specifications Specification Fusion 4000 Fusion 6000 Infusion/ Infusion/ Movement Modes Withdrawal Withdrawal Syringe Sizes 0.5 μL / 140 mL 0.5 μL / 255 mL W(Min/Max) 0.0001 to 0.0001 to Flow Rate Range (Smallest Syringe) 1.08 μL/min 1.5679 μL/min 0.0002 mL/min 0.0002 mL/min Flow Rate Range (Largest Syringe) to 128 mL/min to 128 mL/min 0.9° stepper motor with...
  • Page 15 Specifications (Continued) Specification Fusion 4000 Fusion 6000 Relative Humidity 20% - 80% 20% - 80% RS-232 (DB9 and USB-B), RS-232 (DB9 and USB-B), Data Ports TTL (USB-B) TTL (USB-B) Length 28cm (11in) 28cm (11in) Width 31cm (12in) 26cm (10in) Height 13cm (4.9in)

  • Page 16: Pump Setup

    Pump Setup Powering On/Off the Pump To provide power to the pump, an IEC 60320 C13 cable should be plugged into the power socket on the back of the pump. The cable should be plugged into an appropriate power source (110V or 220V) with proper grounding. Adjust the voltage- converter switch on the back of the pump such that the value displayed on the switch corresponds with the voltage of the power supply.

  • Page 17: Loading A Syringe

    200 mL. The Fusion 6000 can be expanded to 4 channels using the Chemyx 4-Channel 100 mL Syringe Rack accessory. The volume of the Fusion 4000 syringes can vary from a minimum of 0.5 μL up to a maximum of 60 mL and the Fusion 6000 syringe can vary from 0.5 μL to 200 mL.
  • Page 18 5. Loosen the bracket clamp knob for the plunger retaining bracket and adjust the gap such that the plunger cap of the syringe may fit. 6. Unscrew the knob to release the block and slide the pusher block to the right until it is flush against the syringe plunger.
  • Page 19 FUSION 6000 1. If necessary, move and tighten the infusion safety rod (see Adjusting the Safety Rod). 2. To move the pusher block use the Forward and Reverse functions that can be found on the menu screen of the pump. Move the pusher block all the way to the right 3.

  • Page 20: Adjusting The Safety Nut/Stall Rod

    To protect against this potential problem, Fusion 4000 syringe pumps use safety collars and Fusion 6000 use a stall rod to physically stop the pusher block before it can completely depress the syringe plunger. When a pusher block hits the safety mechanism and can no longer move forward, the pump will stop running, emit a long beep, and enter pump-stalled mode.

  • Page 21: Pump Operation

    Pump Operation Operating Interface Limits for selected fields Selected Fields Deselected Field The LCD screen displays a graphical user interface (GUI) from which all the pump settings and run parameters are entered. Whenever an item is currently selected, the color scheme of the element typically turns to a darker shade of the color. For example, the light blue buttons turn dark blue when selected, and the white background surrounding a deselected editable text field turns blue when the field is selected and available for editing.
  • Page 22 NAVIGATING BETWEEN SCREENS All of the screens in the Fusion Series GUI exist in a hierarchy, with the Mode Selection screen at the top. Entering a new screen is performed simply by activating, or tapping, a button or icon that opens the new screen. To return to the previous screen, tap or activate the red “X”...

  • Page 23: Mode Selection Screen

    Mode Selection Screen The Mode Selection screen is the top level menu for the Fusion series pumps. The Fusion 4000 screen allows users to select between pumps and Cycle Mode. The Fusion 6000 screen allows users to select flow and pressure and temperature controlling profiles.

  • Page 24: Pressure & Temperature Settings (Fusion 6000 Only)

    Pressure & Temperature Settings (Fusion 6000 Only) The Temperature Settings screen allows you to control the optional syringe heaters for the Fusion 6000 pump. The options on the screen allow you to start the heater with flow, control temperature, pre-heat the syringe and then start the pump as well as setting a timer on the syringe heater.

  • Page 25: Basic Mode

    Basic Mode Basic Mode (or Single-Step Mode) is used for applications that do not require advanced automation, variable volume and rate settings, step looping, or ramping rates. The Basic Mode screen can be reached by tapping on the water droplet icon on the Mode Selection screen. Basic Mode allows users to select the syringe being used, to set a valid volume and rate, and to choose whether to infuse or withdraw.

  • Page 26: Volume

    When a particular syringe is selected from the list on the right, an Import button will appear next to the selected item. Tapping the Import button (or pressing the Enter key on the navigation keypad) will import the inner diameter associated with the selected syringe and exit the Syringe Library screen.

  • Page 27: Infusion/Withdrawal

    Additionally, high flow rates can exert tremendous pressure within a syringe that may cause glass or plastic syringes to burst. In the case of high-pressure experiments, users should consider using Chemyx Stainless-Steel Syringes and the high-pressure Chemyx Fusion 6000 pump.

  • Page 28: Start-Time Delay

    START-TIME DELAY The Delay field represents the amount of time (in minutes and seconds) to delay starting the pump after the current step begins. When entering this value with the numeric keypad, the decimal key is used to indicate the separation between minutes and seconds.

  • Page 29: Options

    Options The Fusion Series is capable of both infusion and withdrawal. On the systems, an Infusion/Withdrawal toggle button should appear when the Volume field is selected. The bubble form indicates the mode that is currently set and direction that the pusher block will move upon starting the run. Volume Settings screen FLOW-RATE UNITS The flow-rate units determine which units of volume and time will be used for the Volume and Rate fields.

  • Page 31: Multi-Step Mode

    Multi-Step Mode Multi-Step Mode is used for more advanced applications that may require numerous steps, multiple different volume and rate settings, step looping, or ramping rates. The Multi-Step Mode screen can be reached by tapping on the Menu icon on the Mode Selection screen. The pump can only be started in Multi-Step Mode when the Multi-Step Mode screen is showing.

  • Page 32: Total Steps

    TOTAL STEPS The Total Steps field determines how many steps will occur in the method. Each step has independent values for Volume, Rate, Delay, and Infusion/Withdrawal. Upon entering the number of steps, the list on the left of the screen will update to show all of the steps.

  • Page 33: Flow-Rate Units

    FLOW-RATE UNITS Tapping the Volume or Pump Rate button opens a screen that allows flow-rate units to be set. The flow-rate unit determines which unit of volume and time will be used for the Volume and Rate fields for all of the steps. This setting in Multi-Step Mode also changes the units for Basic Mode.

  • Page 34: Step Parameters

    Step Parameters Every step in the multi-step method will have a selectable entry in the list. At the top of the screen you will find a place to enter your syringe size as well as the number of steps the multi-step method to take. Tapping the step will allow you to change the Volume and Rate.

  • Page 35: Pump Control

    PUMP CONTROL The pump’s actions are controlled by the Stop, Pause, and Start keys on the front. In order to start a run, the screen should be showing either the Basic Mode (for basic runs) or Multi-Step Mode (for multi-step runs) main screens. Pressing the Start key in either other these screens will start a run with the currently set parameters.
  • Page 36 RUN STATUS Basic Mode System Status screen The Run Status screen for Basic Mode highlights the current activity of the pump during a run. The Elapsed Time field indicates how much time has passed since the pump has started physically running, not including any start-time delay.
  • Page 37 START OPTIONS When starting the Fusion 4000 pump a display of start options will be shown. User will be required to select one option based on the pump that needs to be started. Other functions are also available to pause and stop the pump once the pump has started.

  • Page 38: System Settings

    System Settings The System Settings screen can be reached by tapping on the Menu icon on the Mode Selection screen. System Settings screen BAUD RATE The baud rate is the rate at which information is transferred through the serial connection. This rate is often limited by the type of serial connection used.
  • Page 39 MOTOR FORCE The Fusion 4000 and Fusion 6000 pumps can generate up to a maximum of 65lbs and 500 lbs of linear force, respectively. Some syringes made of more fragile materials may not be able to withstand the full linear force of the pump. On the Fusion Series pumps, the motor power, and thus the linear force, can be decreased in the System Settings screen.

  • Page 40: Pump Control By Computer

    Pump Control by Computer Cable Requirements Two types of connections are available for external computer control: DB9 and USB, cables for each are available for purchase through Chemyx (call 1-281-277-5499 or visit www.chemyx.com/contact-us). DB9 Serial Cable (Male-to-Female) USB-A to USB-B cable For the DB9 serial connection, a Male-to-Female DB9 cable must be used.

  • Page 41: Com Port Settings

    COM PORT SETTINGS Regardless of the operating system being used, the terminal program controlling the serial connection should use the following connection settings: Baud Rate 9600 or 115200 Data Bits Parity None Stop Bits Flow Control None The baud rate setting for the serial connection must match the baud rate set in the pump settings GUI (See Baud Rate in System Settings).

  • Page 42: Pump Commands

    Pump Commands Regardless of the operating system being used, the terminal program controlling the serial connection should use the following connection settings: Command Description help Displays a list of available commands. Starts the pump with the currently set parameters. The parameters that will run depend upon start which mode (Basic Mode or Multi-Step Mode) the pump touchscreen is showing. Pauses the current pump run. The run can be resumed from this point using the start com- pause mand.
  • Page 43 Command Description Sets the transfer volume. The pump will run until the volume infused or withdrawn equals this volume. This command also sets whether the pump is infusing or withdrawing (Fusion 200 only) and the number of steps used in Multi-Step Mode. X must be an integer or decimal (up to five decimal places) within the volume limits for the syringe (See read limit parameter command). A negative sign can be added in front of any value to indicate a switch to withdrawal mode (Fusion 200 only). For Basic Mode, only one value is required. Entering only one value will automatically switch the pump to Basic Mode. Example set volume set volume 25.0 X,X,X,... To set volumes in Multi-Step Mode, the pump must be manually switched to Multi-Step Mode on the pump. For each step, a value must be entered, separated by commas and no spaces. The number of steps will be automatically adjusted to the number of values entered (i.e., entering only three values will change the number of steps to three). Example set volume 3,-2,4 Returns the transfer volume, transfer rate, and transfer time (in Basic Mode). Returns only the transfer volumes (in Multi-Step Mode). Sets the target time for a pump run. This will adjust the transfer rate so that the run will last for the input time. The target volume will remain the same. This command also sets the number of steps used in Multi-Step Mode.
  • Page 44 Command Description Sets the transfer rate for infusion/withdrawal. X must be an integer or decimal (up to five decimal places) within the rate limits for the syringe (See read limit parameter command). For Basic Mode, only one value is required. Example set rate 1.0 To set rates in Multi-Step Mode, the pump must be manually switched to Multi-Step Mode on the pump. For each step, a value must be entered, separated by commas and no spaces. set rate X,X,X,... Example set rate 1.0,0.5,1.3 If the number of values is less than the number of steps, the remaining steps will gain the same rate value as the last entered value. Any extra values beyond the number of steps will be truncated. Example set rate 0.5/1.0,0.5/1.0,1.3 Returns the flow rate and transfer time (in Basic Mode).
  • Page 45 Command Description Sets the start time delay (in minutes) prior to each step of a pump run. Upon starting the a step, the pump will wait until the delay time elapses before starting to transfer volume. X must be an integer or decimal (up to five decimal places) within the rate limits for the syringe (See read limit parameter command). For Basic Mode, only one value is required. Entering only one value will automatically switch the pump to Basic Mode. Example set delay 1.0 set delay X,X,X,... To set rates in Multi-Step Mode, the pump must be manually switched to Multi-Step Mode on the pump. For each step of Multi-Step Mode, a value must be entered, separated by commas and no spaces. Example set delay 1.0,0.5,1.3 If the number of values is less than the number of steps, the remaining steps will gain the same delay value as the last entered value. Any extra values beyond the number of steps will be truncated.
  • Page 46 Command Description Returns the current status of the pump. The returned integer correlates to the status of the pump. 0: Pump stopped 1: Pump running status 2: Pump paused 3: Pump delayed 4: Pump stalled Returns: integer that represents the current status of the pump. Sets multiple parameters in one command (Basic Mode only). X variables in order: units: see set units command transfer mode: 0-infusion, 1-withdrawal syringe ID: see set diameter command transfer volume: see set volume command;...

  • Page 47: Chemyx Pump Controller Programs

    Chemyx Pump Controller Pro- In addition to the manual control of the pumps through a terminal, Chemyx provides pump controller programs as an unsupported open-source applications written in Python, a LabVIEW package, and a MATLAB package. More information...

  • Page 48: Pump Maintenance

    Pump lubrication should be performed every three months. Approved Lubricants • Engine/motor oil • Silicone oil • Machine oil • Tooling oil or “WD-40” • Lithium-based grease Please contact Chemyx (call +1 281-277-5499 or visit www.chemyx.com/contact-us) to confirm the safe use of a different lubricant.

  • Page 49: Pump Accessories

    Pump Accessories 4-Channel Syringe Rack (Fusion 6000 The Chemyx 4-Channel Syringe Rack for the Fusion 6000 provides users with an expansion of the number of syringes that can be used simultaneously. The 4channel syringe rack can accommodate up to 4...
  • Page 50 ATTACHING THE RACK Plunger Retaining Bracket Fusion 200 Syringe Holder with 10 Channels...
  • Page 51 Appendices Appendix A: Syringe Volume/Diameter Refer- CHEMYX STAINLESS STEEL HAMILTON GLASS Size Diameter Size Diameter 6.00 mL 9.53 mm 0.50 μL 0.10 mm 20.00 mL 19.13 mm 1.00 μL 0.15 mm 50.00 mL 28.6 mm 2.00 μL 0.21 mm 5.00 μL 0.33 mm BD GLASS 10.00 μL 0.48 mm 25.00 μL...
  • Page 52 NORM-JECT PLAS- JMC AIR-TITE PLASTIC Size Diameter Size Diameter 1.00 mL 4.66 mm 1.00 mL 4.70 mm 2.00 mL 6.90 mm 2.50 mL 9.70 mm 2.50 mL 9.10 mm 5.00 mL 12.48 mm 5.00 mL 12.62 mm 10.00 mL 15.89 mm 10.00 mL 14.34 mm 20.00 mL 20.00 mm 20.00 mL...
  • Page 53 TERUMO JAPAN SGE GLASS Size Diameter Size Diameter 25.00 μL 0.73 mm 1.00 mL 4.73 mm 50.00 μL 1.03 mm 1.00 mL 6.50 mm 100.00 μL 1.46 mm 3.00 mL 8.65 mm 250.00 μL 2.30 mm 5.00 mL 13.00 mm 500.00 μL 3.26 mm 10.00 mL 15.80 mm 1.00 mL 4.61 mm 20.00 mL 20.15 mm...
  • Page 54 UNIMETRICS Size Diameter 10.00 μL 0.46 mm 25.00 μL 0.73 mm 50.00 μL 1.03 mm 100.00 μL 1.46 mm 250.00 μL 2.30 mm 500.00 μL 3.26 mm 1000.00 μL 4.61 mm KENDALL MONOJECT PLASTIC Size Diameter 1.00 mL 4.65 mm 3.00 mL 8.94 mm 6.00 mL 12.70 mm 12.00 mL 15.90 mm 20.00 mL...
  • Page 55 Appendix B: Available Parts FUSION SERIES SYRINGE PUMPS Item Description Part Number Fusion 100 Touch 07100 Fusion 200 Touch 07200 Fusion 4000 74000 Fusion 6000 74000 OPTIONS AND ACCESSORIES Item Description Part Number Heating Sleeve (Fusion 6000 only) 50012 4 Channel Rack (Fusion 6000 only) 50009 Pressure Sensor (Fusion 6000 only)
  • Page 56 10905 Cash Rd. Stafford, TX 77477 Webpage: www.chemyx.com Contact Us: www.chemyx.com/contact-us Phone: +1 281-277-5499 Fax: +1 281-277-0045 Office Hours: Monday–Friday, 8:30 am – 5 pm (Central Time) For more articles and tutorial videos, visit: www.chemyx.com/support Follow Us LinkedIn: www.linkedin.com/company/chemyx Twitter: www.twitter.com/chemyxinc...

This manual is also suitable for:

Fusion 6000

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